Helena

Advancing the science behind genomic technology.

We investigate the scientific questions that shape how genomic technologies are built, evaluated and used.

We move the field forward through reproducible research, open methods and computational systems designed for real genomic work.

03 public recordsPrimary records on ZenodoOpen reproducibility material

Current research

Questions first. Claims kept inside the evidence.

01

Preprint / Real-world performance

A Methodological Framework for Real-World Performance Studies of Clinical Variant Classification Platforms at Early Organizational Stages

A route between informal internal testing and formal regulatory adjudication, demonstrated on 97 scored cases.

1 July 2026

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02

Preprint / Clinical variant classification

Evidence Admissibility Is the Load-Bearing Human Gate in Auditable Clinical Variant Classification

Human authorization at evidence admissibility, before a version-locked snapshot enters deterministic classification.

14 July 2026

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03

Preprint / Precision oncology

Robustness and cross-cohort concordance of developmental regulons in endometrial carcinoma

Association, target-set robustness and transportability tested across TCGA-UCEC and CPTAC-UCEC.

2 August 2026

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Find us on

Vladimir Mitev and Helena Bioinformatics research on ZenodoZenodoVladimir Mitev on ORCIDORCIDHelena Bioinformatics on bio.toolsbio.toolsVladimir Mitev on Web of ScienceWeb of ScienceHelena Bioinformatics Validation Studies on OSFOSF